This study investigated cultural dimensions of career decision-making difficulties using the Career Decision-Making Difficulties Questionnaire. Career decision-making difficulties were compared among White, African, Hispanic, and Asian American high school and university students at U.S. schools. Results indicated Asian American students perceived significantly more difficulties in career decision making than other groups, whereas White American students perceived the fewest difficulties. Asian American students reported more difficulties than White and Hispanic American students before the process and more difficulties than White and African American students during the process. Findings are discussed based on perspectives of cultural differences.