Loading...
Analysis of elemental concentration and spectral biomarkers in ischemic muscle of patients with peripheral artery disease
Duraisamy, Nithyanandhi
Duraisamy, Nithyanandhi
Files
Loading...
t15046_Duraisamy.pdf
Adobe PDF, 1.37 MB
Authors
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2015-07
Type
Thesis
Genre
Keywords
Subjects (LCSH)
Electronic thesis
Electronic dissertations
Electronic dissertations
Citation
Abstract
Peripheral arterial disease (PAD) is a chronic progressive narrowing of the arterial lumen due to atherosclerosis (fat, plaque deposition and hardening of arterial walls), which affects approximately 8 million lives in the United States. Patients diagnosed with PAD have increased risks of limb loss and mortality. The classic symptom of PAD is intermittent claudication (IC), defined as calf pain associated with increased metabolic demand on the muscle. Functional testing, such as the ankle brachial index (ABI), measured as the ratio of systolic blood pressure in the ankle to that in the arm, is the most common test for the diagnosis of PAD. The ABI can identify reduced blood flow (due to blockages in the arteries) based on blood pressure differences. However, there is a need to measure more than just abnormal blood flow, it is also critical to measure the effects of compromised blood flow on the skeletal muscle. In this study, we evaluate the hypothesis that differences in muscle elemental composition and biochemical alterations in the diseased tissue could be correlated with clinical diagnosis and may be used to characterize muscle damage severity. These findings may aid in the development of specialized preventive and rehabilitative treatment plans by providing new biological targets based on the specific stage of disease and muscle damage. This will also be a stepping stone toward the development of improved monitoring techniques of muscle damage repair following treatment intervention.
Table of Contents
Description
Thesis (M.S.)--Wichita State University, College of Engingeering, Dept. of Industrial and Manufacturing Engineering
Publisher
Wichita State University
Journal
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Copyright 2015 Nithyanandhi Duraisamy