Organogenesis of the Drosophila respiratory system
Loganathan, Rajprasad Cheng, Yim L. Andrew, Deborah J.
Loganathan, Rajprasad
Cheng, Yim L.
Andrew, Deborah J.
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Issue Date
2016-08-27
Type
Book chapter
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Keywords
Embryo,Tubulogenesis,Organogenesis,Morphogenesis,Trachea,Gene network
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Citation
Loganathan, R., Cheng, Y.L., Andrew, D.J. (2016). Organogenesis of the Drosophila Respiratory System. In: Castelli-Gair Hombría, J., Bovolenta, P. (eds) Organogenetic Gene Networks. Springer, Cham. https://doi.org/10.1007/978-3-319-42767-6_6
Abstract
The trachea (Drosophila respiratory organ) is a highly branched tubular network, which has emerged as a premier model system for the investigation of molecular and cellular mechanisms of tubular organogenesis. Genetic and molecular analyses of tracheal development have implicated an organogenetic network composed of over two hundred genes, several of which function in highly conserved cell signaling pathways. Tracheal construction incorporates the assembly of multicellular, unicellular and subcellular tube architectures, providing an instructive case study for iterative utilization of the same cell signals under diverse developmental contexts. These signals direct cell specification, migration and branch architecture. Assembly of the tracheal tubular network is driven by several morphogenetic processes, which include invagination, collective cell migration, branch fusion, cell shape changes and cell rearrangements. In addition to assembly, the genetic network also serves to control tubule size while exhibiting a remarkable degree of developmental plasticity. Here, we review all of tracheal development from specification of the primordia in early embryos through the acquisition of terminal architecture to the final clearance of the airway coincident with the onset of tracheal function.
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The book chapter can be found here: https://rdcu.be/eBJo9
Publisher
Springer, Cham
Journal
Book Title
Organogenetic gene networks