Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics
Mandadapu, Sivakoteswara Rao Gunnam, Mallikarjuna Reddy Kankanamalage, Anushka C. Galasiti Uy, Roxanne Adeline Z. Alliston, Kevin R. Lushington, Gerald H. Kim, Yunjeong Chang, Kyeong-Ok Groutas, William C.
Mandadapu, Sivakoteswara Rao
Gunnam, Mallikarjuna Reddy
Kankanamalage, Anushka C. Galasiti
Uy, Roxanne Adeline Z.
Alliston, Kevin R.
Lushington, Gerald H.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
Citations
Altmetric:
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2013-11
Type
Article
Genre
Keywords
a-Hydroxyphosphonates,Transition state mimics,Norovirus 3CL protease,Inhibitors
Subjects (LCSH)
Citation
Sivakoteswara Rao Mandadapu, Mallikarjuna Reddy Gunnam, Anushka C. Galasiti Kankanamalage, Roxanne Adeline Z. Uy, Kevin R. Alliston, Gerald H. Lushington, Yunjeong Kim, Kyeong-Ok Chang, William C. Groutas, Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics, Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 21, 1 November 2013, Pages 5941-5944, ISSN 0960-894X, http://dx.doi.org/10.1016/j.bmcl.2013.08.073
Abstract
The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.
Table of Contents
Description
Click on the DOI link to access this article (may not be free)
Publisher
Elsevier
Journal
Bioorganic and Medicinal Chemistry Letters
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
DOI
ISSN
0960-894X