A general approach toward the design of inhibitors of serine proteinases: inhibition of human leukocyte elastase by substituted dihydrouracils
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Authors
Groutas, William C.
Huang, He
Epp, Jeffrey B.
Brubaker, Michael J.
Keller, Charles E.
McClenahan, Jerald J.
Advisors
Issue Date
1992-12
Type
Article
Keywords
Leukocyte elastase , Enzyme inhibitor , Serine proteinase inhibitor , Uracil derivative , Article , Crystallography , Drug synthesis , Enzyme inhibition , Human , Structure activity relation
Citation
William C. Groutas, He Huang, Jeffrey B. Epp, Michael J. Brubaker, Charles E. Keller, Jerald J. McClenahan, A general approach toward the design of inhibitors of serine proteinases: inhibition of human leukocyte elastase by substituted dihydrouracils, Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 12, 1992, Pages 1565-1570, ISSN 0960-894X,https://doi.org/10.1016/S0960-894X(00)80431-X..
Abstract
A general approach toward the rational design of potential inhibitors of serine proteinases is described. The approach is exemplified and validated through the use of appropriate heterocyclic systems in inhibiting human leukocytes elastase (HLE). © 1992. © 2014 Elsevier B.V., All rights reserved.
Table of Contents
Description
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Publisher
Elsevier
Journal
Bioorganic and Medicinal Chemistry Letters
Book Title
Series
PubMed ID
ISSN
1464-3405
0960-894X
0960-894X