Many factors affect the quality of life in breast cancer survivors. The author performed an integrative review of the literature pertaining to quality of life among breast cancer survivors. The 14 research articles that met the inclusion criteria were comprised primarily of observational studies with questionnaires as measurements, interventions with healthcare professional support, targeted women with a diagnosis of breast cancer. Key factors identified in affecting quality of life are: optimism, cancer-related confidence, perceived level of side effects, depression symptoms, social support, social disruption, spirituality, and self-rated quality of life. Current evidence shows that regardless of which factors present, stage at diagnosis, number of co-morbidities, and length since diagnosis did not affect overall quality of life; however, age has a significant influence. These studies are significant, illustrating the individual's overall well-being, instead of solely physical well-being. Many times, patients will make treatment decisions based on what quality of life, not quantity, one may experience.