Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses

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Authors
Chang, Kyeong-Ok
Kim, Yunjeong
Groutas, William C.
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2015-05-14
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Patent
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Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C., inventors. Kansas State University Research Foundation (Manhattan, KS), Wichita State University (Wichita, KS), assignees. Macrocyclic and Peptidomimetic Compounds as Broad-Spectrum Antivirals Against 3C or 3C-Like Proteases of Picornaviruses, Caliciviruses and Coronaviruses. United States patent US 20150133368 A1. 2015, May 14.
Abstract

Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, sapoviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

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WSU inventor: William C. Groutas, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 14/398290 filed May 2, 2013. Patent No: US 20150133368 A1 granted May 14, 2015
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United States Patent and Trademark Office
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