Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one
Groutas, William C. Chong, Lee S. Venkataraman, Radhika
Groutas, William C.
Chong, Lee S.
Venkataraman, Radhika
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
1993-12-15
Type
Article
Genre
Keywords
Comparative Study,Research Support, U.S. Gov't, P.H.S.
Subjects (LCSH)
Cathepsins/blood
Protease Inhibitors/pharmacology
Thiazoles/pharmacology
Protease Inhibitors/pharmacology
Thiazoles/pharmacology
Citation
Biochemical and biophysical research communications. 1993 Dec 15; 197(2): 730-9.
Abstract
A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to be effective inhibitors of cathepsin G.
Table of Contents
Description
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Publisher
Elsevier
Journal
Book Title
Series
Biochemical and biophysical research communications
Biochem. Biophys. Res. Commun.
Biochem. Biophys. Res. Commun.
Digital Collection
Finding Aid URL
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Archival Collection
NLM
PubMed ID
DOI
ISSN
0006-291X