This study examined the correlates of burden of caregivers providing care to people living with HIV/AIDS in rural northern Namibia and the consequences of caregivers' burden on their physical health and mental health. A purposive sampling method was used to recruit a total of 97 primary caregivers (N = 97) in rural Namibia. We found that hunger and HIV stigma were both positively associated with caregiver burden. Caregiver burden was positively related to depression and negatively related to quality of life. The findings underscore the complex relationships between food insecurity and HIV stigma on caregiver burden and the outcomes of burden on quality of life and depressive symptoms. Policy and practice implications are also discussed.