Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
Wen, Shao Yin, X. N. Stevenson, William T.K.
Wen, Shao
Yin, X. N.
Stevenson, William T.K.
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Authors
Wen, Shao
Yin, X. N.
Stevenson, William T.K.
Yin, X. N.
Stevenson, William T.K.
Other Names
Wichita State University. Department of Chemistry
Location
Time Period
Advisors
Original Date
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Issue Date
1991-05-01
Type
Article
Genre
Keywords
In Vitro,Research Support, Non-U.S. Gov't
Subjects (LCSH)
Polymers/chemistry
Citation
Biomaterials. 1991 May; 12(4): 374-84.
Abstract
Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized by NMR spectroscopy and dilute solution viscometry. Relationships between pKa/pKb/pH, solubility and extent of ionization were determined by acid/base titration. Yields and equilibrium water contents of complex coacervates from these polymers were measured, and microcapsule forming systems based on this effect were developed as potential prostheses for organ transplantation. Short term cell viability in these capsules was demonstrated using erythrocytes as a model cell line.
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Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Biomaterials
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NLM
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DOI
ISSN
0142-9612