Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications

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Issue Date
2014-04-18
Embargo End Date
Authors
Seraz, Md Syef
Asmatulu, Ramazan
Chen, Zheng
Ceylan, Muhammet
Mahapatro, Anil
Yang, Shang-You
Advisor
Citation

Md. S. Seraz ; R. Asmatulu ; Z. Chen ; M. Ceylan ; A. Mahapatro, et al. " Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications ", Proc. SPIE 9060, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2014, 90600J (April 18, 2014); doi:10.1117/12.2047255

Abstract

This study deals with two biomedical subjects: corrosion rates of polyelectrolyte-coated magnesium (Mg) alloys, mainly used for biomedical purposes, and antibacterial properties of these alloys. Thin sheets of Mg alloys were coated with cationic polyelectrolyte chitosan (CHI) and anionic polyelectrolyte carboxymethyl cellulose (CMC) using a layer-by-layer coating method and then embedded with antibacterial agents under vacuum. Electrochemical impedance spectroscopy was employed to analyze these samples in order to detect their corrosion properties at different conditions. In the electrochemical analysis section, a corrosion rate of 72 mille inches per year was found in a salt solution for the sample coated with a 12 phosphonic acid self-assembled monolayer and 9 CHI/CMC multilayers. In the antibacterial tests, gentamicin was used to investigate the effects of the drug embedded with the coated surfaces against the Escherichia coli (E. coli) bacteria. Antibacterial studies were tested using the disk diffusion method. Based on the standard diameter of the zone of inhibition chart, the antibacterial diffusion from the surface strongly inhibited bacterial growth in the regions. The largest recorded diameter of the zone of inhibition was 50 mm for the pre-UV treated and gentamicin-loaded sample, which is more than three times the standard diameter.

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