Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications
Seraz, Md Syef Asmatulu, Ramazan Chen, Zheng Ceylan, Muhammet Mahapatro, Anil Yang, Shang-You
Seraz, Md Syef
Asmatulu, Ramazan
Chen, Zheng
Ceylan, Muhammet
Mahapatro, Anil
Yang, Shang-You
Citations
Altmetric:
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2014-04-18
Type
Article
Genre
Keywords
Mg alloy,LBL coating,Antibacterial,Cardiovascular applications
Subjects (LCSH)
Citation
Md. S. Seraz ; R. Asmatulu ; Z. Chen ; M. Ceylan ; A. Mahapatro, et al. " Antibacterial polyelectrolyte-coated Mg alloys for biomedical applications ", Proc. SPIE 9060, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2014, 90600J (April 18, 2014); doi:10.1117/12.2047255
Abstract
This study deals with two biomedical subjects: corrosion rates of polyelectrolyte-coated magnesium (Mg) alloys, mainly used for biomedical purposes, and antibacterial properties of these alloys. Thin sheets of Mg alloys were coated with cationic polyelectrolyte chitosan (CHI) and anionic polyelectrolyte carboxymethyl cellulose (CMC) using a layer-by-layer coating method and then embedded with antibacterial agents under vacuum. Electrochemical impedance spectroscopy was employed to analyze these samples in order to detect their corrosion properties at different conditions. In the electrochemical analysis section, a corrosion rate of 72 mille inches per year was found in a salt solution for the sample coated with a 12 phosphonic acid self-assembled monolayer and 9 CHI/CMC multilayers. In the antibacterial tests, gentamicin was used to investigate the effects of the drug embedded with the coated surfaces against the Escherichia coli (E. coli) bacteria. Antibacterial studies were tested using the disk diffusion method. Based on the standard diameter of the zone of inhibition chart, the antibacterial diffusion from the surface strongly inhibited bacterial growth in the regions. The largest recorded diameter of the zone of inhibition was 50 mm for the pre-UV treated and gentamicin-loaded sample, which is more than three times the standard diameter.
Table of Contents
Description
Click on the DOI link to access the article (may not be free).
Publisher
SPIE
Journal
Book Title
Series
Proceedings SPIE 9060, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2014;v.9060
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
DOI
ISSN
0277-786X