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Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
VanHoose, Lisa Sawers, Youssef Loganathan, Rajprasad Vacek, James L. Stehno-Bittel, Lisa Novikova, Lisa Al-Jarrah, Muhammed Smirnova, Irina V.
VanHoose, Lisa
Sawers, Youssef
Loganathan, Rajprasad
Vacek, James L.
Stehno-Bittel, Lisa
Novikova, Lisa
Al-Jarrah, Muhammed
Smirnova, Irina V.
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2010-09-22
Type
Article
Genre
Keywords
Heart rate variability,Exercise training,Wave amplitude,Diabetic animal,Aerobic exercise training
Subjects (LCSH)
Citation
VanHoose, L., Sawers, Y., Loganathan, R. et al. Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. Cardiovasc Diabetol 9, 56 (2010). https://doi.org/10.1186/1475-2840-9-56
Abstract
Background
Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QTc intervals and decreased heart rate variability (HRV). The severity of DAN has a direct relationship with mortality risk. Aerobic exercise training is a common recommendation for the delay and possible reversal of cardiac dysfunction. Limited research exists on ECG measures for the evaluation of aerobic exercise training in Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes. The objective of this study was to assess whether aerobic exercise training may attenuate diabetes induced ECG changes.
Methods
Male ZDF (obese fa/fa) and control Zucker (lean fa/+) rats were assigned to 4 groups: sedentary control (SC), sedentary diabetic (SD), exercised control (EC) and exercised diabetic (ED). The exercised groups began 7 weeks of treadmill training after the development of diabetes in the ED group. Baseline (prior to the training) and termination measurements included body weight, heart weight, blood glucose and glycated hemoglobin levels and ECG parameters. One way repeated measures ANOVA (group) analyzed within and between subject differences and interactions. Pearson coefficients and descriptive statistics described variable relationships and animal characteristics.
Results
Diabetes caused crucial changes in R wave amplitudes (p < 0.001), heart rate variability (p < 0.01), QT intervals (p < 0.001) and QTc intervals (p < 0.001). R wave amplitude augmentation in SD rats from baseline to termination was ameliorated by exercise, resulting in R wave amplitude changes in ED animals similar to control rats. Aerobic exercise training neither attenuated QT or QTc interval prolongation nor restored decreases in HRV in diabetic rats.
Conclusion
This study revealed alterations in R wave amplitudes, HRV, QT and QTc intervals in ZDF rats. Of these changes, aerobic exercise training was able to correct R wave amplitude changes. In addition, exercise has beneficial effect in this diabetic rat model in regards to ECG correlates of left ventricular mass.
Table of Contents
Description
The article can be found here: https://rdcu.be/eADao
Publisher
BioMed Central
Journal
Cardiovascular Diabetology
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
ISSN
1475-2840