A general approach toward the design of mechanism-based inactivators of serine proteinases: inactivation of human leukocyte elastase by a phthalimide derivative
Groutas, William C. Chong, Lee S. Venkataraman, Radhika Huang, He Epp, Jeffrey B. Kuang, Rongze
Groutas, William C.
Chong, Lee S.
Venkataraman, Radhika
Huang, He
Epp, Jeffrey B.
Kuang, Rongze
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1993-12
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Article
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Keywords
Cathepsin G,Elastase,2 Fluoro 2 Phthalimidoacetic Acid Ethyl Ester,Elastase,Elastase Inhibitor,Serine proteinase inhibitor,Unclassified drug,Article,Controlled study,Drug development,Drug synthesis,Enzyme inhibition,Enzyme kinetics,Human,Human tissue,Leukocyte,Structure activity relation
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Citation
William C. Groutas, Lee S. Chong, Radhika Venkataraman, He Huang, Jeffrey B. Epp, Rongze Kuang, A general approach toward the design of mechanism-based inactivators of serine proteinases: inactivation of human leukocyte elastase by a phthalimide derivative, Bioorganic & Medicinal Chemistry Letters, Volume 3, Issue 12, 1993, Pages 2745-2750, ISSN 0960-894X, https://doi.org/10.1016/S0960-894X(01)80756-3.
Abstract
A general approach toward the design of mechanism-based inhibitors of serine proteinases involving the linking of fragment -CHX-COOR to an appropriate recognition element is described. © 1993. © 2014 Elsevier B.V., All rights reserved.
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Elsevier
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Bioorganic and Medicinal Chemistry Letters
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1464-3405
0960-894X
0960-894X