Albumin-based nanocomposite spheres for advanced drug delivery systems

dc.contributor.authorMisak, Heath Edward
dc.contributor.authorAsmatulu, Ramazan
dc.contributor.authorGopu, Janani Sri
dc.contributor.authorMan, Ka-Poh
dc.contributor.authorZacharias, Nora M.
dc.contributor.authorWooley, Paul H.
dc.contributor.authorYang, Shang-You
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractA novel drug delivery system incorporating human serum albumin, poly(lactic-co-glycolic acid, magnetite nanoparticles, and therapeutic agent(s) was developed for potential application in the treatment of diseases such as rheumatoid arthritis and skin cancer. An oil-in-oil emulsion/solvent evaporation (O/OSE) method was modified to produce a drug delivery system with a diameter of 0.5-2 mu m. The diameter was mainly controlled by adjusting the viscosity of albumin in the discontinuous phase of the O/OSE method. The drug-release study showed that the release of drug and albumin was mostly dependent on the albumin content of the drug delivery system, which is very similar to the drug occlusion-mesopore model. Cytotoxicity tests indicated that increasing the albumin content in the drug delivery system increased cell viability, possibly due to the improved biocompatibility of the system. Overall, these studies show that the proposed system could be a viable option as a drug delivery system in the treatment of many illnesses, such as rheumatoid arthritis, and skin and breast cancers.en_US
dc.identifier.citationMisak, Heath Edward; Asmatulu, Ramazan; Gopu, Janani Sri; Man, Ka-Poh; Zacharias, Nora M.; Wooley, Paul H.; Yang, Shang-You. 2014. Albumin-based nanocomposite spheres for advanced drug delivery systems. Biotechnology Journal Special Issue: Biotech Methods and Advances, vol. 9:no. 1:ppg. 163–170en_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.ispartofseriesBiotechnology Journal;Special Issue: Biotech Methods and Advances, v.9:no.1
dc.subjectHuman serum albuminen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectPoly(lactic-co-glycolic acid)en_US
dc.subjectSubmicrometer spheresen_US
dc.titleAlbumin-based nanocomposite spheres for advanced drug delivery systemsen_US
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