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Effect of BMP-2 adherent to resorbable sutures on cartilage repair: A rat model of xyphoid process
Drummond, Nathan Bruner, Bradley W. Heggeness, Michael H. Dart, Bradley Yang, Shang-You
Drummond, Nathan
Bruner, Bradley W.
Heggeness, Michael H.
Dart, Bradley
Yang, Shang-You
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Yang, S_2020.pdf
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2020-08-26
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Article
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Keywords
Animal model,BMP-2,Meniscal repair,Resorbable suture,Xyphoid process
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Citation
Drummond, N.; W. Bruner, B.; Heggeness, M.H.; Dart, B.; Yang, S.-Y. Effect of BMP-2 Adherent to Resorbable Sutures on Cartilage Repair: A Rat Model of Xyphoid Process. Materials 2020, 13, 3764
Abstract
Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects of Bone morphogenetic protein-2 (BMP-2) soaked sutures for cartilage repair, using a rat model of xyphoid healing. Vicryl-resorbable sutures were presoaked in BMP-2 solutions prior to animal experimentation. Rat xyphoid process (an avascular hyaline cartilage structure) was surgically ruptured followed by repair procedures with regular suture or with sutures that were pre-soaked in BMP-2 solutions. In vitro assessment indicated that presoaking the Vicryl-resorbable sutures with 10 μg/mL BMP-2 resulted in a sustained amount of the growth factor release up to 7 days. Histological analysis suggested that application of this BMP-2 soaked suture on the rat xyphoid process model significantly improved the avascular cartilage healing compared to non-soaked control sutures. In conclusion, data here confirm that the rat xyphoid process repair is a reproducible and inexpensive animal model for meniscus and other cartilage repair. More importantly, coating of BMP-2 on sutures appears a potential avenue to improve cartilage repair and regeneration. Further study is warranted to explore the molecular mechanisms of this strategy.
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© Authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MDPI AG
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Materials
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1996-1944