In 2003, the Youth Behavior Risk Survey reported that 46.7% of high school students had been sexually active.[1] In 2000, 9.1 million of the 18.9 million new cases of STDs came from young people age 15-24.[2] Although the teen pregnancy rates had modestly declined in 2004 for girls 15-19, it slightly increased for girls 10-14.[3] Due to these statistics, there is currently an ongoing debate concerning teenage sexual education in the United States and how to make a greater impact on the attitudes, knowledge, and behavior of adolescents. Purpose: To determine whether Abstinence-Only or Comprehensive sexual education has more of an impact on the attitudes, knowledge and sexual behaviors of adolescents. Methods: An evidence based literature review was completed using published studies involving Abstinence-Only and Comprehensive sexual education. These studies were then evaluated to determine which method has the greatest impact. Results: Comprehensive is given a B recommendation and Abstinence-Only is given a C recommendation. More head to head and randomized controlled trials still need to be completed.