Loading...
A synthetic model of the Nickel superoxide dismutase active site
Freige, Mackenzie
Freige, Mackenzie
Files
Loading...
Abstract
Adobe PDF, 34.93 KB
Authors
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2017-04-04
Type
Abstract
Genre
Keywords
Subjects (LCSH)
Citation
Abstract
Superoxide dismutase (SOD) is an enzyme that facilitates the disproportionation of the superoxide ion (O2-) into molecular oxygen and hydrogen peroxide. In living organisms, the O2- radical is produced during cellular respiration, and the SOD enzyme is essential to break down this toxin. SODs are classified by the metal ion at their active sites, and one class contains a nickel ion (Ni2+/Ni3+). Nickel superoxide dismutase (NiSOD) is the most recently identified SOD. This project aims to synthesize model complexes of the active site of NiSOD in order to better understand this class of protein. Using 2,2'-dithiodibenzaldehyde (DTDB) as a reactant, a new complex with a Ni(II)-N2S2 active site and a thiolate donor was produced. The model complex will be analyzed to determine its structure and properties.
Table of Contents
Description
Second place winner of oral presentations at the 17th Annual Undergraduate Research and Creative Activity Forum (URCAF) held at the Rhatigan Student Center, Wichita State University, April 4, 2017.
Publisher
Wichita State University
Journal
Book Title
Series
URCAF;v.17