Role of temperature in quanta mechanisms of facilitation in the frog neuromuscular junction
Yeghiazarian, Lilit Kaiser, Mark J.
Yeghiazarian, Lilit
Kaiser, Mark J.
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Advisors
Original Date
Digitization Date
Issue Date
1998-08
Type
Article
Genre
Keywords
Temperature change,Computer simulation,Quantum mechanism,Transfer process,Solution Temperature
Subjects (LCSH)
Citation
Yeghiazarian, L. & Kaiser, M. Biol Cybern (1998) 79: 59. https://doi.org/10.1007/s004220050458
Abstract
The results of computer simulations on the
Double Barrier Synapse (DBS) model are presented
which quantify the relationship between the synapse
parameters and the quanta transfer process. The DBS
model is applicable to a variety of states of synaptic
activity, and by changing the synapse parameters it is
possible to simulate various conditions of quanta
transmission. The in¯uence of the bathing solution
temperature change on the synaptic parameters under
di erent conditions of transmitter release in the frog
neuromuscular junction is investigated. Simulations
demonstrate that several synaptic parameters, including
the parameters of the presynaptic membrane, are not
a ected by the temperature change. It is shown that a
stimulation frequency exists at which the steady-state
level of facilitation during a long train of stimuli is the
same for a wide range of temperatures.
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Publisher
Springer-Verlag
Journal
Book Title
Series
Biological Cybernetics;v.79 no.1
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PubMed ID
DOI
ISSN
0340-1200
1432-0770 (online)
1432-0770 (online)