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Broad spectrum antivirals against coronavirus
Chang, Kyeong-Ok Kim, Yunjeong Groutas, William C. Perlman, Stanley
Chang, Kyeong-Ok
Kim, Yunjeong
Groutas, William C.
Perlman, Stanley
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WO/2021/202460
Adobe PDF, 4.8 MB
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2021-10-07
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Chang, K., Kim, Y., Groutas, W.C., Perlman, S., inventors; Wichita State University, Kansas State University Research Foundation, University Of Iowa Research Foundation, assignees. Broad spectrum antivirals against coronavirus. World Intellectual Property Organization WO/2021/202460. 2021, October 7.
Abstract
Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha- ketoamides, and bisulfite salts, and in particular -CH2OH, -CHO, -CH(0H)S03-Na+, and - [0(C=0)Rw]S03-Na+.
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WSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences
International Application No: PCT/US2021/024790 filed March 30, 2021. Patent No: WO/2021/202460 granted October 7, 2021.
International Application No: PCT/US2021/024790 filed March 30, 2021. Patent No: WO/2021/202460 granted October 7, 2021.
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World Intellectual Property Organization
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Status: Publication 2021-10-07