Anaerobically induced production of hybrid monokaryons by heterokaryons of Candida albicans

No Thumbnail Available
Authors
Sarachek, Alvin
Issue Date
1989-01
Type
Article
Language
eng
Keywords
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract

During aerobic replication, balanced heterokaryons (hets) of Candida albicans produced by fusing protoplasts of complementing auxotrophic strains characteristically segregate low frequencies of prototrophic monokaryons bearing hybrid nuclei formed either through karyogamy or unidirectional internuclear genetic transfers within het cells. Anaerobic growth causes exponential inactivation of hets and induces their production of hybrid monokaryons. Both responses are functions of heterokaryosis as such and not the genetic backgrounds of hets. Evidence is presented that (i) the nuclei of anaerobically generated hybrids arise through induction in hets of karyogamy not internuclear genetic transfers and that (ii) the events underlying that induction are different from those responsible for inactivation of the cells.

Description
Click on the DOI link below to access the article (may not be free).
Citation
Mycopathologia. 1989 Jan; 105(1): 39-43.
Publisher
Springer Netherlands
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
0301-486X
EISSN