Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)

No Thumbnail Available
Authors
Groutas, William C.
Ruan, Sumei
Kuang, Rongze
Hook, Jerry B.
Sands, Howard
Advisors
Issue Date
1997-04-28
Type
Article
Keywords
In Vitro , Research Support, Non-U.S. Gov't
Research Projects
Organizational Units
Journal Issue
Citation
Biochemical and biophysical research communications. 1997 Apr 28; 233(3): 697-9.
Abstract

The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).

Table of Contents
Description
Click on the DOI link below to access the article (may not be free).
Publisher
Elsevier
Journal
Book Title
Series
Biochemical and biophysical research communications
Biochem. Biophys. Res. Commun.
URI
http://dx.doi.org/10.1006/bbrc.1997.6526
 http://hdl.handle.net/10057/4301
PubMed ID
DOI
ISSN
0006-291X
EISSN
Collections
CHEM Faculty Publications