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Investigating the mechanical and biological properties of nanoparticles-infused thermosensitive chitosan hydrogels for targeted drug delivery
Saeednia, Leyla
Saeednia, Leyla
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Dissertation
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2016-05
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Electronic dissertations
Electronic dissertations
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Abstract
Targeted drug delivery systems (DDSs) have been widely studied in cancer therapy using
various chemotherapy drugs. Due to the toxicity of these cancer drugs, it is desired to target them
into the tumor site, hence increasing their efficiency and decreasing their overall side effects.
Injectable thermosensitive hydrogels are liquid at lower temperatures before
administering them, but they form a gel when the temperature is increased from room
temperature (21°C) to body temperature (37°C) and are considered to be a promising drug
delivery system. Chitosan (CH) is a natural polysaccharide that has gained a great deal of interest
for various biomedical applications, and it has the capability of making thermosensitive
hydrogels when mixed with β-glycerophosphate (β-GP). Nanotechnology has received
significant attention in biomedical applications, such as drug delivery. Carbon-based materials
have the advantage of being more environmentally and biologically friendly than inorganic
materials. In this study, three types of carbon-based nanoparticles—carbon nanotubes (CNTs),
fullerene (F), and graphene (G)—were used to make CH-based thermosensitive nanohybrid
hydrogels, which were analyzed mechanically, chemically, and biologically in order to evaluate
their potential in drug delivery applications, especially cancer treatment. Structural results
confirmed the formation of physical thermosensitive hybrid hydrogels. The cell viability of
nanoparticle-infused hydrogels were found to be between 80% and 100%. Swelling and
degradation behavior were also investigated and found to be improved with the addition of
nanoparticles. The release behavior of methotrexate as a sample anticancer drug showed a slower release behavior in nanohybrid hydrogels. The nanohybrid hydrogels were found to have
effective anti-tumor effect on cancer cells in vitro.
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Thesis (Ph.D.)-- Wichita State University, College of Engineering, Dept. of Mechanical Engineering
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Wichita State University
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Copyright 2016 Leyla Saeednia