Effects of long-term elastic resistance training on oxidative damage of DNA in older adults

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Authors
Page, Phil
Colado, Juan C.
Saez, Guillermo
Gargallo, Pedro
Hernando, Amaya
Estan, Nuria
Juesas, Alvaro
Munoz, Victor
Tella, Victor
Rogers, Michael E.
Advisors
Issue Date
2017-05
Type
Abstract
Keywords
Research Projects
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Citation
Page, Phil; Colado, Juan C.; Saez, Guillermo; Gargallo, Pedro; Hernando, Amaya; Estan, Nuria; Juesas, Alvaro; Munoz, Victor; Tella, Victor; Rogers, Michael E. Effects of long-term elastic resistance training on oxidative damage of DNA in older adults. Medicine & Science in Sports & Exercise: May 2017 - Volume 49 - Issue 5S - p 541
Abstract

It is theorized that age-related physiological changes are a consequence of the accumulation of random oxidative damage to deoxyribonucleic acid (DNA), lipids, and proteins. The major by-product of oxidative DNA damage, 8-Oxo-7,8-dihydro-2’-deoxyguanosine (8-oxo-dG), is the most extensively analyzed oxidative stress marker. The concentration of this biomarker increases as age increases. A higher concentration of 8-oxo-dG is related to diseases such as Alzheimer’s, osteoporosis and oncogenesis. Despite the multiple benefits of resistance training on the aging process, the effect upon mitochondrial function and oxidative stress in older adults is unknown.

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Publisher
Wolters Kluwer Health, Inc.
Journal
Book Title
Series
Medicine and Science in Sports and Exercie;v.49:no.5
PubMed ID
DOI
ISSN
0195-9131
EISSN