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The association of the ACTN3 R577X genotypes and athlete status - a meta-analysis
Brannan, Deric
Brannan, Deric
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2019-05
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Electronic dissertation
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Electronic dissertations
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Abstract
This study is a meta-analysis interested in research that investigated ACTN3 genotype
frequencies present in different athlete types - endurance, middle distance, or power related. One
of the many factors that determine athletic ability is genetics. One heavily studied gene in that
regard is the ACTN3 R577X polymorphism. ACTN3 is a protein-encoding gene that is only
expressed in type II muscle fibers. Three different hypotheses were formulated: 1) homozygous
ACTN3 RR genotype will show a positive association with power related sports 2) no significant
association of the homozygous minor allele XX will be shown with endurance athletes 3) no
significant association will be shown between middle distance athletes and the heterozygous RX
genotype. The analysis regarding hypothesis 1 revealed a statistically significant association
between the RR genotype and power oriented athletes (OR = 1.4680, 95%CI = 1.0113; 2.1308, Z
= 2.02, p = .04). Results for the analysis regarding hypothesis 2 showed no significant
association between endurance athletes and the XX genotype (OR = .96, 95%CI = .72; 1.29, Z
= .25, p = .80). Analysis for hypothesis 3 also demonstrated a non-significant association
between RX genotypes and middle distance athletes (OR = 0.74, 95%CI = 0.38; 1.45, p = .38).
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Thesis (M.Ed.)-- Wichita State University, College of Applied Studies, Dept. of Human Performance Studies
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Wichita State University
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Copyright 2019 by Deric Brannan
All Rights Reserved