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Time-dependent alterations in rat macrovessels with type 1 diabetes
Searls, Yvonne M. Smirnova, Irina V. VanHoose, Lisa Fegley, Barbara Loganathan, Rajprasad Stehno-Bittel, Lisa
Searls, Yvonne M.
Smirnova, Irina V.
VanHoose, Lisa
Fegley, Barbara
Loganathan, Rajprasad
Stehno-Bittel, Lisa
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2012-01-23
Type
Article
Genre
Keywords
Diabetes,Extracellular matrix proteins
Subjects (LCSH)
Citation
Searls, Yvonne, Smirnova, Irina V., VanHoose, Lisa, Fegley, Barbara, Loganathan, Rajprasad, Stehno-Bittel, Lisa, Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes, Journal of Diabetes Research, 2012, 278620, 11 pages, 2012. https://doi.org/10.1155/2012/278620
Abstract
Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality. This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes. While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria. Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals. These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals. In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.
Table of Contents
Description
Academic Editor: Mark A. Yorek
Publisher
Hindawi Publishing Corporation
Journal
Journal of Diabetes Research
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
ISSN
2314-6745
2314-6753
2314-6753