Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism
Bhakta, Mehul N. Wimalasena, Kandatege
Bhakta, Mehul N.
Wimalasena, Kandatege
An error occurred retrieving the object's statistics
Authors
Bhakta, Mehul N.
Wimalasena, Kandatege
Wimalasena, Kandatege
Other Names
Wichita State University. Department of Chemistry
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2002-03-06
Type
Article
Genre
Keywords
Research Support, U.S. Gov't, P.H.S.
Subjects (LCSH)
Citation
Journal of the American Chemical Society. 2002 Mar 6; 124(9): 1844-5.
Abstract
The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a single-electron-transfer (SET) mechanism was later challenged in favor of the C(alpha)-H abstraction mechanism. In the present study, a series of N-alkyl-N-cyclopropyl-p-chloroaniline probes have been used to examine whether the P450-catalyzed N-dealkylations proceed through a C(alpha)-H abstraction and/or a SET mechanism, using phenobarbital-induced rat liver microsomal P450 enzymes as a model system. While the findings are highly consistent with a C(alpha)-H abstraction mechanism, further experimental evidence may be necessary to completely rule out the SET mechanism.
Table of Contents
Description
Full text of this article is not available in SOAR.
Publisher
American Chemical Society
Journal
Book Title
Series
Journal of the American Chemical Society
J. Am. Chem. Soc.
J. Am. Chem. Soc.
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
NLM
PubMed ID
DOI
ISSN
0002-7863