Cytotoxicity of release products from magnetic nanocomposites in targeted drug delivery
Wamocha, Humphrey Lusenaka Misak, Heath Edward Song, Zheng Chu, H. Y. Chen, Y.Y. Asmatulu, Ramazan Yang, Shang-You Ho, J. C.
Wamocha, Humphrey Lusenaka
Misak, Heath Edward
Song, Zheng
Chu, H. Y.
Chen, Y.Y.
Asmatulu, Ramazan
Yang, Shang-You
Ho, J. C.
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2011-11-09
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Journal of biomaterials applications. 2011 Nov 9. [Epub ahead of print]
Abstract
The efficacy of chemotherapy can be significantly improved if the therapeutic agent remains localized at the afflicted area and released at controlled rates. Such a targeted drug delivery can be achieved using magnetic nanocomposite (MNC), which incorporates drug and magnetic nanoparticles in biodegradable polymer microspheres. Reported here are results from an in vitro study on drug release rate and cytotoxicity of other release products from MNC. The model system contains an anti-cancer chemotherapy agent 5-flurouracil (5-FU) and (Co(0.5)Zn(0.5))Fe(2)O(4) in poly(lactic-co-glycolic acid) (PLGA) matrix produced by an oil/oil emulsion technique. Cell proliferation data indicate a sustained release of 5-FU for mouse macrophage cell eradication, whereas other microsphere components of magnetic nanoparticles and PLGA have little cytotoxic effects.
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Sage Publications
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Journal of Biomaterials Applications
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1530-8022
0885-3282
0885-3282