Harm reduction strategies in the community includes the work of practitioners, activists, and researchers conducting community-based work in domestic and international settings to alleviate pain and suffering for people who use drugs (PWUD) by providing services to meet their needs. This themed issue features a wide variety of community examples of harm reduction efforts that have been developed to reduce stigma associated with substance use. The articles focused on creating culturally appropriate messaging for opioid users while at the same time decriminalizing substance use and emphasizing the importance of implementing a social determinants of health framework in the community, including gender-specific care and ensuring safe substance use and connecting youth with services. © 2025 Taylor & Francis Group, LLC.