Analysis of 1-methyl-4-phenylpyridinium derivatives in caenorhabtis elegans

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Murphy, David
Kadigamuwa, Chamila C.
Mapa, Mapa S.T.
Wimalasena, Kandatege
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Murphy, David, Kadigamuwa, Chamila, Mapa, Mapa. 2018. Analysis of 1-methyl-4-phenylpyridinium derivatives in caenorhabtis elegans -- In Proceedings: 14th Annual Symposium on Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 42

Parkinson's disease (PD) is a neurodegenerative disease that affects more than 10 million people worldwide and costs 25 billion dollars in the United States alone. Despite its notoriety, the etiology of PD not fully understood. Parkinson's is characterized by the loss of dopaminergic neurons in the substantia nigra and results in disrupted motor movements such as trembling and shaking. Currently, there is no cure for the disease and current treatments are mostly used to reduce the symptoms. The rate of PD seems to be on the rise and currently the disease is believed to be associated with environmental factors. A synthetic chemical 1-methyl-4-phenylpyridium (MPP+), has been extensively used as a model for environmental/chemical causes of PD. Chemicals structurally similar to MPP+ were tested in our lab and have been shown to be selectively toxic to dopaminergic cells within in vitro models. Additionally, they also seem to utilize a similar mechanism of action. To validate the physiological significance of these in vitro model findings, parallel sets of experiments should be done in an in vivo system. Caenorhabtis elegans has been used as an in vivo or live animal model for a variety of diseases due to its ease of use and genetic malleability. In the present study we show that these chemicals cause similar damage to dopaminergic neurons parallel to MPP+. The structures of these chemicals will lead to new insights on how the disease is progressed as well as development of preventative and treatment strategies of PD.

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Presented to the 14th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Rhatigan Student Center, Wichita State University, April 27, 2018.
Research completed in the Department of Chemistry, Fairmount College of Liberal Arts and Sciences
Wichita State University
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v. 14
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