Potential mechanism-based inhibitors of proteolytic enzymes
Groutas, William C. Brubaker, Michael J. Venkataraman, Radhika Epp, Jeffrey B. Houser-Archield, Nadene Chong, Lee S. McClenahan, Jerald J.
Groutas, William C.
Brubaker, Michael J.
Venkataraman, Radhika
Epp, Jeffrey B.
Houser-Archield, Nadene
Chong, Lee S.
McClenahan, Jerald J.
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1992
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Article
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Keywords
Elastase,1h Isoindole 1,3(2h) Dione Derivative,Elastase inhibitor,Saccharin derivative,Succinimide derivative,Unclassified drug,Article,Enzyme inhibition,Human,Human cell,Neutrophil,Structure activity relation,Synthesis
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Citation
William C. Groutas, Michael J. Brubaker, Radhika Venkataraman, Jeffrey B. Epp, Nadene Houser-Archield, Lee S. Chong, Jerald J. McClenahan, Potential mechanism-based inhibitors of proteolytic enzymes, Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 2, 1992, Pages 175-180, ISSN 0960-894X, https://doi.org/10.1016/S0960-894X(01)80445-5.
Abstract
The design, synthesis, and inhibitory activity toward human neutropil elastase, of a series of potential mechanims-based inhibitors is described. The design, synthesis, and inhibitory activity toward human neutrophile elastase, of a series of potential mechanism-based inhibitor's (I-III) is described. © 1992. © 2014 Elsevier B.V., All rights reserved.
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Elsevier
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Bioorganic and Medicinal Chemistry Letters
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1464-3405
0960-894X
0960-894X