Geographic atrophy progression secondary to age-related macular degeneration: Five years of follow-up
Sadeghi, Elham Valsecchi, Nicola Vupparaboina, Sharat Chandra Mehrotra, Kunaal Vupparaboina, Kiran Kumar Bollepalli, Sandeep Chandra Sahel, Jose-Alain Eller, Andrew W. Chhablani, Jay
Sadeghi, Elham
Valsecchi, Nicola
Vupparaboina, Sharat Chandra
Mehrotra, Kunaal
Vupparaboina, Kiran Kumar
Bollepalli, Sandeep Chandra
Sahel, Jose-Alain
Eller, Andrew W.
Chhablani, Jay
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Issue Date
2024-10-24
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Article
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Keywords
Age-related macular degeneration,Geographic atrophy,Growth rate
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Citation
Sadeghi E, Valsecchi N, Vupparaboina SC, et al. Geographic atrophy progression secondary to age-related macular degeneration: Five years of follow-up. European Journal of Ophthalmology. 2024;0(0). doi:10.1177/11206721241287252
Abstract
Purpose: To study the progression of geographic atrophy (GA) secondary to age-related macular degeneration over a five-year follow-up. Methods: Eyes with GA included to assess demographic data, yearly optical coherence tomography (OCT) findings and the GA growth rate on infra-red (IR) images. Results: A total of 41 eyes of 29 patients were included with a mean age of 81.76 ± 6.37 at baseline, and 65.51% were females. Over five years, there was a significant increase in the mean GA area from 8.44 ± 8.98 mm² to 13.32 ± 10.07 mm² (P < 0.001), with an annual growth rate of 1.14 ± 0.78 mm². The annual growth rates in females were slightly higher compared to males (1.29 ± 0.89 mm2 vs 0.96 ± 0.49 mm2, p = 0.569), and in smokers was slightly higher than non-smokers (1.35 ± 0.85 mm2 vs 0.94 ± 0.66 mm2, p = 0.100). Larger GA areas at the baseline showed higher GA progression in mm2 per year (P = 0.04). Smaller GA areas and fovea-spared GA at the baseline exhibited a larger percentage increase (P < 0.001 and P = 0.015, respectively). There was a lower GA progression rate in eyes with outer retinal tubulations (ORT) (P = 0.027), yet no significant correlation was found between GA progression and other OCT features. Conclusions: Smaller, fovea-sparing GA eyes experienced a more substantial proportional increase over five years. Also, The presence of ORT was associated with a slower rate of GA progression. Additionally, we observed a trend of faster GA growth in smokers and female genders. © The Author(s) 2024.
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SAGE Publications Ltd
Journal
European Journal of Ophthalmology
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11206721