Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

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Issue Date
1999-08-02
Authors
Groutas, William C.
Schechter, Norman M.
He, Shu
Yu, Hongyi
Huang, Peng
Tu, Juan
Advisor
Citation

Bioorganic & medicinal chemistry letters. 1999 Aug 2; 9(15): 2199-204.

Abstract

A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.

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