Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model

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Authors
Misak, Heath Edward
Zacharias, Nora M.
Song, Zheng
Hwang, S.
Man, Ka-Poh
Asmatulu, Ramazan
Yang, Shang-You
Advisors
Issue Date
2013-03
Type
Article
Keywords
Skin cancer , Magnetic target drug delivery , Polymeric delivery system , In vivo testing
Research Projects
Organizational Units
Journal Issue
Citation
Misak, Heath Edward; Zacharias, N.; Song, Z.; Hwang, S.; Man, K.-P.; Asmatulu, Ramazan; Yang, Shang-You. 2013. Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model, Journal of Biotechnology, v.164 no.1 pp.130-136
Abstract

Albumin/drug loaded magnetic nanocomposite spheres were fabricated using an oil-in-oil emulsion/solvent evaporation method, and tested on a mouse model (experimental squamous cell carcinoma) to determine the efficacy of the drug delivery system (DDS) on skin cancer. This novel DDS consists of human serum albumin, poly(lactic-co-glycolic acid) (PLGA), 5-fluorouracil (5-Fu), magnetic nanoparticles (10 nm) and fluorescent labeling molecule (diphenylhexatriene). One of the major purposes of using albumin is that it likely provides internal binding to and retention by the inflammatory tissues to reduce the amount of magnetic nanoparticles needed in the drug loaded microspheres (750–1100 nm). This study is aimed at reducing many negative side effects of conventionally used chemotherapy drugs by localizing the chemotherapy drug, controlling the release of the therapeutic agent and encouraging uptake of the DDS into cancerous cells. A group of mice treated with (1) the magnetic targeted DDS were compared to the other three groups, including, (2) DDS without a magnet, (3) 5-Fu local injection, and (4) untreated groups. The fluorescent tracer was ubiquitously identified inside the tumor tissue, and the DDS/tumor tissue boundary presented a leaky interface. The test results clearly showed that the magnetic targeted DDS exhibited significantly superior therapeutic effects in treating the skin cancer, with the increased efficacy to halt the tumor growth.

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Publisher
Elsevier
Journal
Book Title
Series
Journal of Biotechnology;v.164 no.1
PubMed ID
DOI
ISSN
0168-1656
EISSN