Investigating MTX-Loaded magnetic nanocomposite particles for treatment of rheumatoid arthritis
Usta, Aybala Man, Ka-Poh Strong, Nora M. Misak, Heath Edward Wooley, Paul H. Asmatulu, Ramazan
Usta, Aybala
Man, Ka-Poh
Strong, Nora M.
Misak, Heath Edward
Wooley, Paul H.
Asmatulu, Ramazan
Citations
Altmetric:
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2020-04-01
Type
Article
Genre
Keywords
Albumin,Collagen-induced arthritis,Methotrexate,Nanoparticles,Targeted drug delivery
Subjects (LCSH)
Citation
Usta, Aybala; Man, Ka-Poh; Strong, Nora M.; Misak, Heath Edward; Wooley, Paul H.; Asmatulu, Ramazan. 2020. Investigating MTX-Loaded magnetic nanocomposite particles for treatment of rheumatoid arthritis. Journal of Magnetism and Magnetic Materials, vol. 499:art. no. 166171
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that initially leads to inflammation in the lining of a joint and other parts of the body, then progresses and causes deformity. It occurs when the immune system attacks the body tissue. Treatments help to mitigate symptoms and impede the progression of this disease; however, it can bring about a range of side effects. In a current study, methotrexate hydrate (MTX)-loaded magnetic nanocomposite spheres were fabricated and examined for their potential to treat collagen-induced arthritis (CIA) in the murine model. The carriers contain MTX, albumin, poly lactic-co-glycolic acid (PLGA), and magnetic nanoparticles (NPs), thereby allowing the drug carriers to accumulate at the targeted limb using a magnet that is attached outside the body. A release rate study of these drug delivery systems concluded a mean of six to seven days for the release of the effective dosage. Also, it was revealed that mice treated with the drug carriers using a magnet to target the carriers brought better results in the overall progression of the disease compared to mice that were treated with only carriers but did not receive a magnet to target the carriers. Analysis of the paw scores of arthritis-induced mice demonstrated a progression in the studied paws. Moreover, these results were stated with a 95% confidence interval revealing that paws treated with the targeted carrier showed lower scores and subsequently a better outcome. These results are further supported by the review of micro-computed tomography (micro-CT) scans of the paws.
Table of Contents
Description
Click on the DOI link to access the article (may not be free).
Publisher
Elsevier B.V.
Journal
Book Title
Series
Journal of Magnetism and Magnetic Materials;v.499:art. no.166171
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
DOI
ISSN
0304-8853