Dual function inhibitors of relevance to chronic obstructive pulmonary disease

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Issue Date
2011-05-15
Embargo End Date
Authors
Dou, Dengfeng
He, Guijia
Alliston, Kevin R.
Groutas, William C.
Advisor
Citation

Bioorganic & medicinal chemistry letters. 2011 May 15; 21(10): 3177-80.

Abstract

The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.

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