Dual function inhibitors of relevance to chronic obstructive pulmonary disease
Dou, Dengfeng He, Guijia Alliston, Kevin R. Groutas, William C.
Dou, Dengfeng
He, Guijia
Alliston, Kevin R.
Groutas, William C.
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2011-05-15
Type
Article
Genre
Keywords
Research Support, N.I.H., Extramural
Subjects (LCSH)
Citation
Bioorganic & medicinal chemistry letters. 2011 May 15; 21(10): 3177-80.
Abstract
The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.
Table of Contents
Description
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Publisher
Elsevier
Journal
Bioorganic and Medicinal Chemistry Letters
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
NLM
PubMed ID
DOI
ISSN
1464-3405
0960-894X
0960-894X