Toxicokinetics of organic contaminants in Hyalella azteca
Nuutinen, Susanna Landrum, Peter F. Schuler, Lance J. Kukkonen, Jussi V. K. Lydy, Michael J.
Nuutinen, Susanna
Landrum, Peter F.
Schuler, Lance J.
Kukkonen, Jussi V. K.
Lydy, Michael J.
Citations
Altmetric:
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2003-05
Type
Article
Genre
Keywords
Research Support, U.S. Gov't, Non-P.H.S.
Subjects (LCSH)
Citation
Archives of environmental contamination and toxicology. 2003 May; 44(4): 467-75.
Abstract
Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity.
Table of Contents
Description
Click on the DOI link below to access the article (may not be free).
Publisher
Springer New York
Journal
Archives of Environmental Contamination and Toxicology
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
NLM
PubMed ID
DOI
ISSN
0090-4341