The significance of viscous flow properties in the theory of operation of a nephron

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Lieberstein, H. Melvin
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1969
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Abstract

The salient feature of a nephron is its tiny size, 6-10? in radius, since the fourth-power law requires a tiny flow rate even from a large pressure gradient. Along closely folded hairpin loops that are present in the nephrons of birds and mammals and are called loops of Henle, a salt concentration gradient forms in the ambient medullary tissue. Urine collects in this tissue in ducts, equilibrates with it osmotically, and produces a final product hypertonic to blood. Other authors explain the mechanism of this loop in terms of a hypothesis of active extrusion of a small amount of sodium from one branch of the loop and operation of a countercurrent multiplication principle. By close attention to realistic physical principles we construct a model that does not use this hypothesis but produces in numerical studies the observed concentration gradient and an amplification of this effect with length. A much weaker assumption than similar ones made in other models, that two salt concentrations take on stationary values, causes a linear initial value problem for a (2�2) first-order ordinary differential equation system to replace a (4�4) first-order partial differential equation system. Basic mechanisms used, such as back diffusion, were of no importance in previous square law models. � 1969.

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Mathematical Biosciences
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255564
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