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Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
Burns, Dennis H. English, Douglas S.
Burns, Dennis H.
English, Douglas S.
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EP3408270A1
Adobe PDF, 28.05 MB
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2018-12-05
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Burns, D.H., English, D.S., inventors; Wichita State University, assignee. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. European Patent Office EP3408270A1. 2018, December 5.
Abstract
Abstract not available for EP3408270A1 – abstract of corresponding document: WO2017132561A1.
Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
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WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: EP17745007A filed January 27, 2017. Patent No: EP3408270A1 granted December 5, 2018.
Application No: EP17745007A filed January 27, 2017. Patent No: EP3408270A1 granted December 5, 2018.
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European Patent Office
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Status: Active; Anticipated expiration: 2037-01-27