This article examines the breadth and depth of anti-Americanism in contemporary Latin America. Using individual-level data from 2012, we employ regression analysis to understand why some Latin American citizens are more likely than others to distrust the government of the United States. By examining the attitudes of citizens of countries that are part of different groupings such as the Bolivarian Alliance for the Americas and the Pacific Alliance we find great variation in the levels and predictors of anti-Americanism. While citizens' ideology is a common predictor in most countries, other variables such as the receipt of remittances, the perception of insecurity, and nationalism appear as predictors in only some. Furthermore, although there is a positive correlation between presidential approval and anti-Americanism in countries where leaders have an overtly anti-American discourse, this relationship disappears in countries where the president is perceived as neutral, and it is inverse in countries where the president is perceived as pro-American.