Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

No Thumbnail Available
Issue Date
2011-10-15
Authors
Dou, Dengfeng
Tiew, Kok-Chuan
He, Guijia
Mandadapu, Sivakoteswara Rao
Aravapalli, Sridhar
Alliston, Kevin R.
Kim, Yunjeong
Chang, Kyeong-Ok
Groutas, William C.
Advisor
Citation

Bioorganic & medicinal chemistry. 2011 Oct 15; 19(20): 5975-83.

Abstract

A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 µM, TD(50) 50 µM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.

Table of Content
Description
Click on the DOI link below to access the article (may not be free).
publication.page.dc.relation.uri