Medication nonadherence contributes to poor outcomes in patients with heart failure. The purpose of this project was to determine Whether a self-directed, Web-based medical technology. MyMedSchedule.com (R), could improve medication adherence. Thirty-three heart failure patients participated in a pre/post-intervention exploratory design. A self-directed technology did not significantly improve medication adherence, z = -1.661, P = .097 (pre-interventionscores, mean = 6.44,SD 1.38; post-interventionscores, mean = 6.89, SD = 1.09); however, participants expressed comfort (82%), satisfaction (15%), and confidence (15%) using the technology. Other positive outcomes Were also identified: Technology-based strategies have the potential to improve adherence and reduce Poor outcomes.