Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide
Groutas, William C. Stanga, Michael A. Castrisos, J.C. Schatz, E. J. Brubaker, Michael J.
Groutas, William C.
Stanga, Michael A.
Castrisos, J.C.
Schatz, E. J.
Brubaker, Michael J.
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Issue Date
1990-10-01
Type
Article
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Keywords
In Vitro,Research Support, U.S. Gov't, P.H.S.
Subjects (LCSH)
Citation
Journal of pharmaceutical sciences. 1990 Oct; 79(10): 886-8.
Abstract
A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. The cationic inhibitor having an isobutyl side chain as the P1 residue (3) was found to be the most effective. Human leukocyte cathepsin G and chymotrypsin are also inactivated by these compounds.
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Full text of this article is not available in SOAR.
Publisher
John Wiley and Sons
Journal
Book Title
Series
Journal of pharmaceutical sciences
J Pharm Sci
J Pharm Sci
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NLM
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DOI
ISSN
0022-3549