Albumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatment

No Thumbnail Available
Authors
Abedin, Farhana
Anwar, Md. Rajib
Asmatulu, Ramazan
Yang, Shang-You
Issue Date
2015-07
Type
Article
Language
en_US
Keywords
Drug delivery , Albumin , Magnetic nanoparticles , Nanotechnology , Breast cancer , Cytotoxicity , Drug release
Research Projects
Organizational Units
Journal Issue
Alternative Title
Abstract

Albumin-based drug-carrying micro-composite spheres were fabricated and studied to evaluate their potentials for breast cancer treatment. Magnetic nanoparticles and albumin were incorporated within poly(D l-lactide-co-glycolide) microspheres to increase accumulation of the microspheres at the target site. Two chemotherapeutics, cyclophosphamide and 5-fluorouracil, were encapsulated into the microspheres. The drug-release study revealed an initial burst of drug and then sustained release by diffusion. A Fourier transform infrared spectroscopy study confirmed the presence of all components of the drug delivery system. An in vitro study using fibroblast cells (3T3) and breast cancer cells (MDA-486) exhibited an effective cytotoxicity behavior when exposed to the drug delivery system in a dose- and time-dependent manner. The therapeutic influence of the drug delivery system was evaluated in vivo using a nude mouse breast cancer model. A continuous decrease in tumor size was observed in groups treated with microspheres containing the chemotherapeutics, whereas mice treated with direct chemotherapy without drug delivery system showed less efficacy and suggested tumor relapse after cessation of treatment. The enhanced therapeutic influence of the drug delivery system may be attributed to the increased uptake of the microspheres by malignant cells due to the presence of albumin and magnetic force. The bioavailability of chemotherapeutics at the target site was further increased due to the sustained release of the drugs by diffusion following the burst release. Continuous investigations will optimize the size of the drug delivery system and portions of the target driving-force components (magnetic nanoparticles and albumin) in the drug delivery system to maximize its therapeutic efficacy and minimize potential long-term side effects.

Description
Click on the DOI link to access the article (may not be free).
Citation
Farhana Abedin, Md R Anwar, Ramazan Asmatulu, and Shang-You Yang Albumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatment J Biomater Appl July 2015 30: 38-49, first published on January 30, 2015
Publisher
SAGE Publications
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
0885-3282
EISSN