Loading and release of doxorubicin with magnetic nanotubes

No Thumbnail Available
Authors
Bai, Xia
Wang, Xiang
English, Douglas S.
Lee, Sang Bok
Advisors
Issue Date
2015-03
Type
Article
Keywords
Magnetic nanotubes , Superparamagnetic iron oxide nanoparticles , Doxorubicin , pH-dependent controlled release , Encapsulation , Degradation
Research Projects
Organizational Units
Journal Issue
Citation
Bai, X., Wang, X., English, D. and Lee, S. B. (2015), Loading and Release of Doxorubicin with Magnetic Nanotubes#. Bulletin of the Korean Chemical Society, 36: 772–776. doi: 10.1002/bkcs.10141
Abstract

In this work, we study magnetic nanotubes (MNTs) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18-silane and pyridine-silane. By tuning the interaction between the drug molecules and inner surfaces of MNTs via pH, Dox can be effectively encapsulated at pH 7.2 and released at pH 4.5. The successful loading of Dox is confirmed with confocal microscopy studies. The release profiles of Dox from modified MNTs are detected by spectrofluorophotometry, with bare MNTs as control. With proper modifications, MNTs can be used for pH-dependent, controlled release of drug molecules.

Table of Contents
Description
Click on the URL to access this article (may not be free).
Publisher
John Wiley & Sons, Inc.
Journal
Book Title
Series
Bulletin of the Korean Chemical Society;v.36:no.3
PubMed ID
DOI
ISSN
0253-2964
EISSN