Characterization of oligodendrocyte progenitor cell differentiation on co-electrospun nanofibers of PCL with gelatin
Bikesh Shrestha, Muhammet Ceylan, Alex Moon (2013). Characterization of Oligodendrocyte Progenitor Cell Differentiation on Co-electrospun Nanofibers of PCL with Gelatin -- In Proceedings: 9th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p.75-76
Axonal re-myelination in injured central nervous system (CNS) has been a scientific challenge. Focal delivery of Oligodendrocyte Progenitor Cells (OPCs) provides promising approach. We used a novel bioengineering technique to create co-electrospun nanofibers of Gelatin and Poly-?-caprolactone (PCL) to be used as a scaffold for neural tissue regeneration. Growth and differentiation of Oligodendrocyte progenitor cells (OPCs) (from neonatal rat brain) on the scaffold were studied. Our study revealed that Gelatin/PCL nanofibers provide a hospitable substrate for OPC growth and differentiation. Our long term goal is to develop a scaffold that bridges the injured spinal cord (SC) and aid its functional recovery.
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Research completed at the Department of Biological Sciences, College of Liberal Arts & Sciences and the Department of Mechanical Engineering, College of Engineering