Characterization of oligodendrocyte progenitor cell differentiation on co-electrospun nanofibers of PCL with gelatin

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Shrestha, Bikesh
Ceylan, Muhammet
Moon, Alex
Yao, Li
Asmatulu, Ramazan

Bikesh Shrestha, Muhammet Ceylan, Alex Moon (2013). Characterization of Oligodendrocyte Progenitor Cell Differentiation on Co-electrospun Nanofibers of PCL with Gelatin -- In Proceedings: 9th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p.75-76


Axonal re-myelination in injured central nervous system (CNS) has been a scientific challenge. Focal delivery of Oligodendrocyte Progenitor Cells (OPCs) provides promising approach. We used a novel bioengineering technique to create co-electrospun nanofibers of Gelatin and Poly-?-caprolactone (PCL) to be used as a scaffold for neural tissue regeneration. Growth and differentiation of Oligodendrocyte progenitor cells (OPCs) (from neonatal rat brain) on the scaffold were studied. Our study revealed that Gelatin/PCL nanofibers provide a hospitable substrate for OPC growth and differentiation. Our long term goal is to develop a scaffold that bridges the injured spinal cord (SC) and aid its functional recovery.

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Paper presented to the 9th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Marcus Welcome Center, Wichita State University, May 8, 2013.
Research completed at the Department of Biological Sciences, College of Liberal Arts & Sciences and the Department of Mechanical Engineering, College of Engineering