Porphyrin molecules that selectively bind to the phosphatidylglycerol (PG) head group, a lipid found in bacterial membrane

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Issue Date
2019-04-26
Authors
Seelam, Bhusi Reddy
Advisor
Burns, Dennis H.
Citation

Seelam, Bhusi Reddy, Burns, Dennis H. 2019. Porphyrin molecules that selectively bind to the phosphatidylglycerol (PG) head group, a lipid found in bacterial membrane -- In Proceedings: 15th Annual Symposium on Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University

Abstract

Porphyrin molecules that selectively bind to the phosphatidylglycerol (PG) head group, a lipid found in bacterial membrane have been previously reported by our research group. A tetrakis-ammonium glycine picket porphyrin exhibits high binding affinity, selectivity and could penetrate the bacterial cell wall as elucidated by solution studies, Fluorescence correlation spectroscopy (FCS) and bacterial studies. Here in we report on modified ammonium picket porphyrin molecules, which are able to bind to PG at the membrane interface. Complex formation effectively increases the size of the head group and changes the overall charge from negative to positive, increasing the membrane permeability.

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Description
Presented to the 15th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Rhatigan Student Center, Wichita State University, April 26, 2019.
Research completed in the Department of Chemistry, Fairmount College of Liberal Arts and Sciences
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