Loading...
Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation
Singh, Navdeep Batra, Uma Kumar, Kamal Ahuja, Neeraj Mahapatro, Anil
Singh, Navdeep
Batra, Uma
Kumar, Kamal
Ahuja, Neeraj
Mahapatro, Anil
Files
Loading...
Article
Adobe PDF, 19.46 MB
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2022-05-15
Type
Preprint
Genre
Keywords
Mg alloys,Corrosion resistance,Bio-functionality,Conversion coating,Multilayered hybrid coating,Coating failures
Subjects (LCSH)
Citation
Singh, N., Batra, U., Kumar, K., Ahuja, N., & Mahapatro, A. (2023). Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation. Bioactive Materials, 19. https://doi.org/https://doi.org/10.1016/j.bioactmat.2022.05.009
Abstract
Mg and its alloys evince strong candidature for biodegradable bone implants, cardiovascular stents, and wound closing devices. However, their rapid degradation rate causes premature implant failure, constraining clinical applications. Bio-functional surface coatings have emerged as the most competent strategy to fulfill the diverse clinical requirements, besides yielding effective corrosion resistance. This article reviews the progress of biodegradable and advanced surface coatings on Mg alloys investigated in recent years, aiming to build up a comprehensive knowledge framework of coating techniques, processing parameters, performance measures in terms of corrosion resistance, adhesion strength, and biocompatibility. Recently developed conversion and deposition type surface coatings are thoroughly discussed by reporting their essential therapeutic responses like osteogenesis, angiogenesis, cytocompatibility, hemocompatibility, anti-bacterial, and controlled drug release towards in-vitro and in-vivo study models. The challenges associated with metallic, ceramic and polymeric coatings along with merits and demerits of various coatings have been illustrated. The use of multilayered hybrid coating comprising a unique combination of organic and inorganic components has been emphasized with future perspectives to obtain diverse bio-functionalities in a facile single coating system for orthopedic implant applications.
Table of Contents
Description
This is an open access article under the CC BY-NC-ND license.
Publisher
Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
Journal
Book Title
Series
Bioactive Materials
Vol. 19
Vol. 19
Digital Collection
Finding Aid URL
Use and Reproduction
Archival Collection
PubMed ID
DOI
ISSN
2452-199X