A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation
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Authors
Meece, Frederick A.
Jayasinghe, Champika P.
Histand, Gary
Burns, Dennis H.
Advisors
Issue Date
2009-04-17
Type
Article
Keywords
Citation
The Journal of organic chemistry. 2009 Apr 17; 74(8): 3156-9.
Abstract
A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction.
Table of Contents
Description
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Publisher
American Chemical Society
Journal
Book Title
Series
The Journal of organic chemistry
J. Org. Chem.
J. Org. Chem.
PubMed ID
DOI
ISSN
1520-6904
0022-3263
0022-3263