A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation
Meece, Frederick A. Jayasinghe, Champika P. Histand, Gary Burns, Dennis H.
Meece, Frederick A.
Jayasinghe, Champika P.
Histand, Gary
Burns, Dennis H.
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2009-04-17
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The Journal of organic chemistry. 2009 Apr 17; 74(8): 3156-9.
Abstract
A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction.
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American Chemical Society
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The Journal of organic chemistry
J. Org. Chem.
J. Org. Chem.
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1520-6904
0022-3263
0022-3263