Purpose: The purpose of this paper is to examine the role that information systems (IS) artifacts (IS for automation and IS for analytics) and process standardization play in enhancing different dimensions of supply chain agility (SCA) (sensing, comprehending and responding). Design/methodology/approach: Data collected through the survey approach was used to examine the research model. The results were analyzed based on regression analysis. Various tests were conducted to validate the results of the mediation hypotheses. Findings: The results show that IS for analytics has a significant association with all dimensions of SCA and mediates the relationship between IS for automation and SCA's sensing and comprehending dimensions. In addition, process standardization directly and uniquely influences the comprehending and responding dimensions of SCA. Research limitations/implications: The assessment of the relationship between different IS features in the context of SCA enhancement contributes to theory development in the area of IS-enabled supply chains. Furthermore, investing in both process and IS-related initiatives offers unique value in the context of supply chains. The data collection approach limited us to a cross-sectional analysis, whereas longitudinal data could have offered deeper insights. Practical implications: IS artifacts and process-based initiatives can be leveraged for organizational capability enhancement. Organizations that are vigilant, analysis driven and take quick actions, invest in IS-based tools that support analytics. The highest impact of these tools is visible in the enhancement of the comprehending dimension of SCA. Originality/value: Prior research does not explicitly examine the interplay among the different IS artifacts. Furthermore, process-centric initiatives can also be used in conjunction with or as an alternative to IS-based initiatives. The originality of this work stems from jointly evaluating the role of IS artifacts and process standardization in making the supply chain more agile. © 2024, Emerald Publishing Limited.