Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

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Authors
Kuang, Rongze
Venkataraman, Radhika
Ruan, Sumei
Groutas, William C.
Advisors
Issue Date
1998-03-03
Type
Article
Keywords
Research Support, Non-U.S. Gov't , Research Support, U.S. Gov't, P.H.S.
Research Projects
Organizational Units
Journal Issue
Citation
Bioorganic & medicinal chemistry letters. 1998 Mar 3; 8(5): 539-44.
Abstract

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).

Table of Contents
Description
Full text of this article is not available in SOAR.
Publisher
Elsevier
Journal
Book Title
Series
Bioorganic & medicinal chemistry letters
Bioorg. Med. Chem. Lett.
URI
http://hdl.handle.net/10057/4357
PubMed ID
DOI
ISSN
0960-894X
EISSN
Collections
CHEM Faculty Publications