Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

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Issue Date
1998-03-03
Authors
Kuang, Rongze
Venkataraman, Radhika
Ruan, Sumei
Groutas, William C.
Advisor
Citation

Bioorganic & medicinal chemistry letters. 1998 Mar 3; 8(5): 539-44.

Abstract

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).

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